Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease

Th17 is a newly identified T-cell lineage that secretes proinflammatory cytokine IL-17. Th17 cells have been shown to play a critical role in mediating autoimmune diseases such as EAE, colitis, and arthritis, but their role in the pathogenesis of graft-versus-host disease (GVHD) is still unknown. He...

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Main Authors: Yi, Tangsheng, Zhao, Dongchang, Lin, Chia-Lei, Zhang, Chunyan, Chen, Ying, Todorov, Ivan, LeBon, Thomas, Kandeel, Fouad, Forman, Stephen, Zeng, Defu
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2008
Fag:
Transplantation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518909/
https://ncbi.nlm.nih.gov/pubmed/18596226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-12-126987
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