Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease

In acute graft-versus-host disease (GVHD), naive donor CD4(+) T cells recognize alloantigens on host antigen-presenting cells and differentiate into T helper (Th) subsets (Th1, Th2, and Th17 cells), but the role of Th subsets in GVHD pathogenesis is incompletely characterized. Here we report that, i...

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Detalhes bibliográficos
Main Authors: Yi, Tangsheng, Chen, Ying, Wang, Lin, Du, Gong, Huang, Daniel, Zhao, Dongchang, Johnston, Heather, Young, James, Todorov, Ivan, Umetsu, Dale T., Chen, Lieping, Iwakura, Yoichiro, Kandeel, Fouad, Forman, Stephen, Zeng, Defu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756212/
https://ncbi.nlm.nih.gov/pubmed/19602708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-05-219402
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