Thymic Damage, Impaired Negative Selection, and Development of Chronic Graft-versus-Host Disease Caused by Donor CD4(+) and CD8(+) T Cells

Prevention of chronic graft-versus-host disease (cGVHD) remains a major challenge in allogeneic hematopoietic cell transplantation (HCT), due to limited understanding of cGVHD pathogenesis and lack of appropriate animal models. Here, we report that, in classical acute GVHD models with C57BL/6 donors...

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Main Authors: Wu, Tao, Young, James S., Johnston, Heather, Ni, Xiong, Deng, Ruishu, Racine, Jeremy, Wang, Miao, Wang, Audrey, Todorov, Ivan, Wang, Jianmin, Zeng, Defu
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746979/
https://ncbi.nlm.nih.gov/pubmed/23709681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300657
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