Donor B cells in Transplants Augment Clonal Expansion and Survival of Pathogenic CD4(+) T cells That Mediate Autoimmune-like Chronic GVHD

We reported that both donor CD4(+) T and B cells in transplants were required for induction of an autoimmune-like chronic graft versus host disease (cGVHD) in a murine model of DBA/2 donor to BALB/c recipient, but mechanisms whereby donor B cells augment cGVHD pathogenesis remain unknown. Here, we r...

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Detalhes bibliográficos
Main Authors: Young, James S, Wu, Tao, Chen, Yuhong, Zhao, Dongchang, Liu, Hongjun, Yi, Tangsheng, Johnston, Heather, Racine, Jeremy, Li, Xiaofan, Wang, Audrey, Todorov, Ivan, Zeng, Defu
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746987/
https://ncbi.nlm.nih.gov/pubmed/22649197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200677
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