In Vivo Activation of Duocarmycin–Antibody Conjugates by Near-Infrared Light

[Image: see text] Near-IR photocaging groups based on the heptamethine cyanine scaffold present the opportunity to visualize and then treat diseased tissue with potent bioactive molecules. Here we describe fundamental chemical studies that enable biological validation of this approach. Guided by rat...

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Xehetasun bibliografikoak
Argitaratua izan da:ACS Cent Sci
Egile Nagusiak: Nani, Roger R., Gorka, Alexander P., Nagaya, Tadanobu, Yamamoto, Tsuyoshi, Ivanic, Joseph, Kobayashi, Hisataka, Schnermann, Martin J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2017
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408340/
https://ncbi.nlm.nih.gov/pubmed/28470051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.7b00026
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