In Vivo Activation of Duocarmycin–Antibody Conjugates by Near-Infrared Light

[Image: see text] Near-IR photocaging groups based on the heptamethine cyanine scaffold present the opportunity to visualize and then treat diseased tissue with potent bioactive molecules. Here we describe fundamental chemical studies that enable biological validation of this approach. Guided by rat...

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Bibliografiske detaljer
Udgivet i:ACS Cent Sci
Main Authors: Nani, Roger R., Gorka, Alexander P., Nagaya, Tadanobu, Yamamoto, Tsuyoshi, Ivanic, Joseph, Kobayashi, Hisataka, Schnermann, Martin J.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2017
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408340/
https://ncbi.nlm.nih.gov/pubmed/28470051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.7b00026
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