Cyanine Photocages Enable the Near-IR Light Activation of Antibody-Drug Conjugates

Despite significant progress in the clinical application of antibody drug conjugates (ADCs), novel cleavage strategies that provide improved selectivity are still needed. Near-IR light could provide a targetable, biocompatible external stimulus to initiate drug release. Here we report the first appr...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Nani, Roger R., Gorka, Alexander P., Nagaya, Tadanobu, Kobayashi, Hisataka, Schnermann, Martin J.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743669/
https://ncbi.nlm.nih.gov/pubmed/26403799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201507391
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