Impact of C4′-O-Alkyl Linker on in Vivo Pharmacokinetics of Near-Infrared Cyanine/Monoclonal Antibody Conjugates

Near-infrared (NIR) fluorophores have several advantages over visible-light fluorophores, including superior tissue penetration and lower autofluorescence. We recently accessed a new class of readily synthesized NIR cyanines containing a novel C4′-O-alkyl linker, which provides both high chemical st...

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Pubblicato in:Mol Pharm
Autori principali: Sato, Kazuhide, Nagaya, Tadanobu, Nakamura, Yuko, Harada, Toshiko, Nani, Roger R., Shaum, James B., Gorka, Alexander P., Kim, Insook, Paik, Chang H., Choyke, Peter L., Schnermann, Martin J., Kobayashi, Hisataka
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575776/
https://ncbi.nlm.nih.gov/pubmed/26261913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00472
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