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In Vivo Activation of Duocarmycin–Antibody Conjugates by Near-Infrared Light
[Image: see text] Near-IR photocaging groups based on the heptamethine cyanine scaffold present the opportunity to visualize and then treat diseased tissue with potent bioactive molecules. Here we describe fundamental chemical studies that enable biological validation of this approach. Guided by rat...
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| Pubblicato in: | ACS Cent Sci |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical Society
2017
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5408340/ https://ncbi.nlm.nih.gov/pubmed/28470051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.7b00026 |
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