Curcumin Dictates Divergent Fates for the Central Salt Bridges in Amyloid-β(40) and Amyloid-β(42)

There are three specific regions in the Amyloid beta (Aβ) peptide sequence where variations cause enhanced toxicity in Alzheimer’s disease: the N-terminus, the central salt bridge, and the C-terminus. Here, we investigate if there is a close conformational connection between these three regions, whi...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Chandra, Bappaditya, Mithu, Venus Singh, Bhowmik, Debanjan, Das, Anand Kant, Sahoo, Bankanidhi, Maiti, Sudipta, Madhu, Perunthiruthy K.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2017
Assuntos:
Proteins
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5406280/
https://ncbi.nlm.nih.gov/pubmed/28445751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.02.043
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