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Major Reaction Coordinates Linking Transient Amyloid-β Oligomers to Fibrils Measured at Atomic Level

The structural underpinnings for the higher toxicity of the oligomeric intermediates of amyloidogenic peptides, compared to the mature fibrils, remain unknown at present. The transient nature and heterogeneity of the oligomers make it difficult to follow their structure. Here, using vibrational and...

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Dettagli Bibliografici
Pubblicato in:Biophys J
Autori principali: Chandra, Bappaditya, Bhowmik, Debanjan, Maity, Barun Kumar, Mote, Kaustubh R., Dhara, Debabrata, Venkatramani, Ravindra, Maiti, Sudipta, Madhu, Perunthiruthy K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567595/
https://ncbi.nlm.nih.gov/pubmed/28834717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.06.068
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