Major Reaction Coordinates Linking Transient Amyloid-β Oligomers to Fibrils Measured at Atomic Level

The structural underpinnings for the higher toxicity of the oligomeric intermediates of amyloidogenic peptides, compared to the mature fibrils, remain unknown at present. The transient nature and heterogeneity of the oligomers make it difficult to follow their structure. Here, using vibrational and...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Chandra, Bappaditya, Bhowmik, Debanjan, Maity, Barun Kumar, Mote, Kaustubh R., Dhara, Debabrata, Venkatramani, Ravindra, Maiti, Sudipta, Madhu, Perunthiruthy K.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2017
Assuntos:
Proteins
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567595/
https://ncbi.nlm.nih.gov/pubmed/28834717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.06.068
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