Zn(++) Binding Disrupts the Asp(23)-Lys(28) Salt Bridge without Altering the Hairpin-Shaped Cross-β Structure of Aβ(42) Amyloid Aggregates

Observations like high Zn(2+) concentrations in senile plaques found in the brains of Alzheimer's patients and evidences emphasizing the role of Zn(2+) in amyloid-β (Aβ)-induced toxicity have triggered wide interest in understanding the nature of Zn(2+)-Aβ interaction. In vivo and in vitro stud...

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Detalhes bibliográficos
Main Authors: Mithu, Venus Singh, Sarkar, Bidyut, Bhowmik, Debanjan, Chandrakesan, Muralidharan, Maiti, Sudipta, Madhu, Perunthiruthy K.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2011
Assuntos:
Spectroscopy, Imaging, and Other Techniques
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3297803/
https://ncbi.nlm.nih.gov/pubmed/22261072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.10.023
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