Curcumin Alters the Salt Bridge-containing Turn Region in Amyloid β(1–42) Aggregates

Amyloid β (Aβ) fibrillar deposits in the brain are a hallmark of Alzheimer disease (AD). Curcumin, a common ingredient of Asian spices, is known to disrupt Aβ fibril formation and to reduce AD pathology in mouse models. Understanding the structural changes induced by curcumin can potentially lead to...

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Detalhes bibliográficos
Main Authors: Mithu, Venus Singh, Sarkar, Bidyut, Bhowmik, Debanjan, Das, Anand Kant, Chandrakesan, Muralidharan, Maiti, Sudipta, Madhu, Perunthiruthy K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036251/
https://ncbi.nlm.nih.gov/pubmed/24599958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.519447
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