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Fission Yeast Apc15 Stabilizes MCC-Cdc20-APC/C Complexes, Ensuring Efficient Cdc20 Ubiquitination and Checkpoint Arrest

During mitosis, cells must segregate the replicated copies of their genome to their daughter cells with extremely high fidelity. Segregation errors lead to an abnormal chromosome number (aneuploidy), which typically results in disease or cell death [1]. Chromosome segregation and anaphase onset are...

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Publicat a:Curr Biol
Autors principals: May, Karen M., Paldi, Flora, Hardwick, Kevin G.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5405113/
https://ncbi.nlm.nih.gov/pubmed/28366744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2017.03.013
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