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Fission Yeast Apc15 Stabilizes MCC-Cdc20-APC/C Complexes, Ensuring Efficient Cdc20 Ubiquitination and Checkpoint Arrest

During mitosis, cells must segregate the replicated copies of their genome to their daughter cells with extremely high fidelity. Segregation errors lead to an abnormal chromosome number (aneuploidy), which typically results in disease or cell death [1]. Chromosome segregation and anaphase onset are...

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Foilsithe in:Curr Biol
Main Authors: May, Karen M., Paldi, Flora, Hardwick, Kevin G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cell Press 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5405113/
https://ncbi.nlm.nih.gov/pubmed/28366744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2017.03.013
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