APC15 mediates CDC20 auto-ubiquitylation by APC/C(MCC) and MCC disassembly

The anaphase-promoting complex/cyclosome bound to CDC20 (APC/C(CDC20)) initiates anaphase by ubiquitylating B-type cyclins and securin. During chromosome bi-orientation, CDC20 assembles with MAD2, BUBR1 and BUB3 into a mitotic checkpoint complex (MCC) which inhibits substrate recruitment to the APC/...

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Autors principals: Uzunova, Kristina, Dye, Billy T., Schutz, Hannelore, Ladurner, Rene, Petzold, Georg, Toyoda, Yusuke, Jarvis, Marc A., Brown, Nicholas G., Poser, Ina, Novatchkova, Maria, Mechtler, Karl, Hyman, Anthony A., Stark, Holger, Schulman, Brenda A., Peters, Jan-Michael
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498062/
https://ncbi.nlm.nih.gov/pubmed/23007861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2412
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