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APC15 mediates CDC20 auto-ubiquitylation by APC/C(MCC) and MCC disassembly
The anaphase-promoting complex/cyclosome bound to CDC20 (APC/C(CDC20)) initiates anaphase by ubiquitylating B-type cyclins and securin. During chromosome bi-orientation, CDC20 assembles with MAD2, BUBR1 and BUB3 into a mitotic checkpoint complex (MCC) which inhibits substrate recruitment to the APC/...
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| Hlavní autoři: | , , , , , , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3498062/ https://ncbi.nlm.nih.gov/pubmed/23007861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2412 |
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