Mechanism of APC/C(CDC20) activation by mitotic phosphorylation

Chromosome segregation and mitotic exit are initiated by the 1.2-MDa ubiquitin ligase APC/C (anaphase-promoting complex/cyclosome) and its coactivator CDC20 (cell division cycle 20). To avoid chromosome missegregation, APC/C(CDC20) activation is tightly controlled. CDC20 only associates with APC/C i...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Qiao, Renping, Weissmann, Florian, Yamaguchi, Masaya, Brown, Nicholas G., VanderLinden, Ryan, Imre, Richard, Jarvis, Marc A., Brunner, Michael R., Davidson, Iain F., Litos, Gabriele, Haselbach, David, Mechtler, Karl, Stark, Holger, Schulman, Brenda A., Peters, Jan-Michael
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868491/
https://ncbi.nlm.nih.gov/pubmed/27114510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604929113
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