Cryo EM of Mitotic Checkpoint Complex-bound APC/C reveals reciprocal and conformational regulation of ubiquitin ligation

The Mitotic Checkpoint Complex (MCC) coordinates proper chromosome biorientation on the spindle with ubiquitination activities of CDC20-activated Anaphase-promoting complex/Cyclosome (APC/C(CDC20)). APC/C(CDC20) and two E2s, UBE2C and UBE2S, catalyze ubiquitination through distinct architectures for...

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Udgivet i:Mol Cell
Main Authors: Yamaguchi, Masaya, VanderLinden, Ryan, Weissmann, Florian, Qiao, Renping, Dube, Prakash, Brown, Nicholas G., Haselbach, David, Zhang, Wei, Sidhu, Sachdev S., Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148128/
https://ncbi.nlm.nih.gov/pubmed/27522463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.07.003
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