Mps1(Mph1) Kinase Phosphorylates Mad3 to Inhibit Cdc20(Slp1)-APC/C and Maintain Spindle Checkpoint Arrests

The spindle checkpoint is a mitotic surveillance system which ensures equal segregation of sister chromatids. It delays anaphase onset by inhibiting the action of the E3 ubiquitin ligase known as the anaphase promoting complex or cyclosome (APC/C). Mad3/BubR1 is a key component of the mitotic checkp...

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Vydáno v:PLoS Genet
Hlavní autoři: Zich, Judith, May, Karen, Paraskevopoulos, Konstantinos, Sen, Onur, Syred, Heather M., van der Sar, Sjaak, Patel, Hitesh, Moresco, James J., Sarkeshik, Ali, Yates, John R., Rappsilber, Juri, Hardwick, Kevin G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755545/
https://ncbi.nlm.nih.gov/pubmed/26882497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005834
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