Mps1(Mph1) Kinase Phosphorylates Mad3 to Inhibit Cdc20(Slp1)-APC/C and Maintain Spindle Checkpoint Arrests

The spindle checkpoint is a mitotic surveillance system which ensures equal segregation of sister chromatids. It delays anaphase onset by inhibiting the action of the E3 ubiquitin ligase known as the anaphase promoting complex or cyclosome (APC/C). Mad3/BubR1 is a key component of the mitotic checkp...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Genet
Prif Awduron: Zich, Judith, May, Karen, Paraskevopoulos, Konstantinos, Sen, Onur, Syred, Heather M., van der Sar, Sjaak, Patel, Hitesh, Moresco, James J., Sarkeshik, Ali, Yates, John R., Rappsilber, Juri, Hardwick, Kevin G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2016
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755545/
https://ncbi.nlm.nih.gov/pubmed/26882497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005834
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