Kinase Activity of Fission Yeast Mph1 Is Required for Mad2 and Mad3 to Stably Bind the Anaphase Promoting Complex

Defects in chromosome segregation result in aneuploidy, which can lead to disease or cell death [1, 2]. The spindle checkpoint delays anaphase onset until all chromosomes are attached to spindle microtubules in a bipolar fashion [3, 4]. Mad2 is a key checkpoint component that undergoes conformationa...

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Main Authors: Zich, Judith, Sochaj, Alicja M., Syred, Heather M., Milne, Laura, Cook, Atlanta G., Ohkura, Hiro, Rappsilber, Juri, Hardwick, Kevin G.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315010/
https://ncbi.nlm.nih.gov/pubmed/22281223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2011.12.049
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