Mps1(Mph1) Kinase Phosphorylates Mad3 to Inhibit Cdc20(Slp1)-APC/C and Maintain Spindle Checkpoint Arrests

The spindle checkpoint is a mitotic surveillance system which ensures equal segregation of sister chromatids. It delays anaphase onset by inhibiting the action of the E3 ubiquitin ligase known as the anaphase promoting complex or cyclosome (APC/C). Mad3/BubR1 is a key component of the mitotic checkp...

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Bibliografiset tiedot
Julkaisussa:PLoS Genet
Päätekijät: Zich, Judith, May, Karen, Paraskevopoulos, Konstantinos, Sen, Onur, Syred, Heather M., van der Sar, Sjaak, Patel, Hitesh, Moresco, James J., Sarkeshik, Ali, Yates, John R., Rappsilber, Juri, Hardwick, Kevin G.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2016
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755545/
https://ncbi.nlm.nih.gov/pubmed/26882497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005834
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