APC15 drives the turnover of MCC-Cdc20 to make the Spindle Assembly Checkpoint responsive to kinetochore attachment

Faithful chromosome segregation during mitosis depends on the Spindle Assembly Checkpoint (SAC) that monitors kinetochore attachment to the mitotic spindle. Unattached kinetochores generate mitotic checkpoint proteins complexes (MCCs) that bind and inhibit the Anaphase Promoting Complex/Cyclosome (A...

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Bibliographic Details
Main Authors: Mansfeld, Jörg, Collin, Philippe, Collins, Mark O., Choudhary, Jyoti S., Pines, Jonathon
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188299/
https://ncbi.nlm.nih.gov/pubmed/21926987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2347
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