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The Mitotic Checkpoint Complex binds a second CDC20 to inhibit active APC/C
The Spindle Assembly Checkpoint (SAC) maintains genomic stability by delaying chromosome segregation until the last chromosome has attached to the mitotic spindle. The SAC prevents the Anaphase Promoting Complex/Cyclosome (APC/C) ubiquitin ligase from recognising Cyclin B and securin by catalysing t...
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| Publié dans: | Nature |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4312099/ https://ncbi.nlm.nih.gov/pubmed/25383541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13911 |
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