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The Mitotic Checkpoint Complex binds a second CDC20 to inhibit active APC/C

The Spindle Assembly Checkpoint (SAC) maintains genomic stability by delaying chromosome segregation until the last chromosome has attached to the mitotic spindle. The SAC prevents the Anaphase Promoting Complex/Cyclosome (APC/C) ubiquitin ligase from recognising Cyclin B and securin by catalysing t...

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Publicado en:Nature
Main Authors: Izawa, Daisuke, Pines, Jonathon
Formato: Artigo
Idioma:Inglês
Publicado: 2014
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312099/
https://ncbi.nlm.nih.gov/pubmed/25383541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13911
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