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Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation
The spindle assembly checkpoint (SAC) is essential to ensure proper chromosome segregation and thereby maintain genomic stability. The SAC monitors chromosome attachment, and any unattached chromosomes generate a “wait anaphase” signal that blocks chromosome segregation. The target of the SAC is Cdc...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3461516/ https://ncbi.nlm.nih.gov/pubmed/23007648 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201205170 |
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