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The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction
The Spindle Assembly Checkpoint (SAC) is required to block sister chromatid separation until all chromosomes are properly attached to the mitotic apparatus. The SAC prevents cells entering anaphase by inhibiting the ubiquitination of cyclin B1 and securin by the Anaphase Promoting Complex/Cyclosome...
Bewaard in:
| Hoofdauteurs: | , , , |
|---|---|
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2008
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2635557/ https://ncbi.nlm.nih.gov/pubmed/18997788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1799 |
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