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The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C

The Spindle Assembly Checkpoint (SAC) ensures genomic stability by preventing sister chromatid separation until all chromosomes are attached to the spindle. It catalyzes the production of the Mitotic Checkpoint Complex (MCC), which inhibits Cdc20 to inactivate the Anaphase Promoting Complex/Cyclosom...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Di Fiore, Barbara, Wurzenberger, Claudia, Davey, Norman E., Pines, Jonathon
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5179498/
https://ncbi.nlm.nih.gov/pubmed/27939943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.11.006
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