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Population pharmacokinetics of temsirolimus and sirolimus in children with recurrent solid tumours: a report from the Children's Oncology Group

AIMS: Temsirolimus is an inhibitor of the mammalian target of rapamycin (mTOR). Pharmacokinetic (PK) characterization of temsirolimus in children is limited and there is no paediatric temsirolimus population PK model available. The objective of this study was to simultaneously characterize the PK of...

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Bibliografiset tiedot
Julkaisussa:Br J Clin Pharmacol
Päätekijät: Mizuno, Tomoyuki, Fukuda, Tsuyoshi, Christians, Uwe, Perentesis, John P., Fouladi, Maryam, Vinks, Alexander A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5401981/
https://ncbi.nlm.nih.gov/pubmed/28000286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13181
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