A Phase I Study of Cixutumumab (IMC-A12) in Combination with Temsirolimus (CCI-779) in Children with Recurrent Solid Tumors: A Children’s Oncology Group Phase 1 Consortium Report

PURPOSE: To determine the maximum tolerated dose (MTD), dose-limiting toxicities (DLT), pharmacokinetics, and biologic effects of cixutumumab administered in combination with temsirolimus to children with refractory solid tumors. EXPERIMENTAL DESIGN: Cixutumumab and temsirolimus were administered in...

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Udgivet i:Clin Cancer Res
Main Authors: Fouladi, Maryam, Perentesis, John P., Wagner, Lars M., Vinks, Alexander A., Reid, Joel M., Ahern, Charlotte, Thomas, George, Mercer, Carol A., Krueger, Darcy A., Houghton, Peter J., Doyle, L. Austin, Chen, Helen, Weigel, Brenda, Blaney, Susan M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454739/
https://ncbi.nlm.nih.gov/pubmed/25467181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0595
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