Population pharmacokinetics of temsirolimus and sirolimus in children with recurrent solid tumours: a report from the Children's Oncology Group

AIMS: Temsirolimus is an inhibitor of the mammalian target of rapamycin (mTOR). Pharmacokinetic (PK) characterization of temsirolimus in children is limited and there is no paediatric temsirolimus population PK model available. The objective of this study was to simultaneously characterize the PK of...

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Bibliografische gegevens
Gepubliceerd in:Br J Clin Pharmacol
Hoofdauteurs: Mizuno, Tomoyuki, Fukuda, Tsuyoshi, Christians, Uwe, Perentesis, John P., Fouladi, Maryam, Vinks, Alexander A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2016
Onderwerpen:
Paediatric Clinical Pharmacology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5401981/
https://ncbi.nlm.nih.gov/pubmed/28000286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13181
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