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Population pharmacokinetics of temsirolimus and sirolimus in children with recurrent solid tumours: a report from the Children's Oncology Group

AIMS: Temsirolimus is an inhibitor of the mammalian target of rapamycin (mTOR). Pharmacokinetic (PK) characterization of temsirolimus in children is limited and there is no paediatric temsirolimus population PK model available. The objective of this study was to simultaneously characterize the PK of...

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Detaylı Bibliyografya
Yayımlandı:Br J Clin Pharmacol
Asıl Yazarlar: Mizuno, Tomoyuki, Fukuda, Tsuyoshi, Christians, Uwe, Perentesis, John P., Fouladi, Maryam, Vinks, Alexander A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5401981/
https://ncbi.nlm.nih.gov/pubmed/28000286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13181
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