Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis

With some advances in modern medicine (such as cancer chemotherapy, broad exposure to antibiotics, and immunosuppression), the incidence of opportunistic fungal pathogens such as Candida albicans has increased. Cases of drug resistance among these pathogens have become more frequent, requiring the d...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Hargrove, Tatiana Y., Friggeri, Laura, Wawrzak, Zdzislaw, Qi, Aidong, Hoekstra, William J., Schotzinger, Robert J., York, John D., Guengerich, F. Peter, Lepesheva, Galina I.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2017
Konular:
Enzymology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399120/
https://ncbi.nlm.nih.gov/pubmed/28258218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.778308
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