Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design(1)

Rapidly multiplying cancer cells synthesize greater amounts of cholesterol to build their membranes. Cholesterol-lowering drugs (statins) are currently in clinical trials for anticancer chemotherapy. However, given at higher doses, statins cause serious side effects by inhibiting the formation of ot...

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Bibliografiske detaljer
Udgivet i:J Lipid Res
Main Authors: Hargrove, Tatiana Y., Friggeri, Laura, Wawrzak, Zdzislaw, Sivakumaran, Suneethi, Yazlovitskaya, Eugenia M., Hiebert, Scott W., Guengerich, F. Peter, Waterman, Michael R., Lepesheva, Galina I.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2016
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959870/
https://ncbi.nlm.nih.gov/pubmed/27313059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M069229
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