Formation of Azole-Resistant Candida albicans by Mutation of Sterol 14-Demethylase P450

The sterol 14-demethylase P450 (CYP51) of a fluconazole-resistant isolate of Candida albicans, DUMC136, showed reduced susceptibility to this azole but with little change in its catalytic activity. Twelve nucleotide substitutions, resulting in four amino acid changes, were identified in the DUMC136...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Asai, Kentaro, Tsuchimori, Noboru, Okonogi, Kenji, Perfect, John R., Gotoh, Osamu, Yoshida, Yuzo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89127/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10223930/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.5.1163
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