Formation of Azole-Resistant Candida albicans by Mutation of Sterol 14-Demethylase P450

The sterol 14-demethylase P450 (CYP51) of a fluconazole-resistant isolate of Candida albicans, DUMC136, showed reduced susceptibility to this azole but with little change in its catalytic activity. Twelve nucleotide substitutions, resulting in four amino acid changes, were identified in the DUMC136...

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Bibliographic Details

Published in:	Antimicrob Agents Chemother
Main Authors:	Asai, Kentaro, Tsuchimori, Noboru, Okonogi, Kenji, Perfect, John R., Gotoh, Osamu, Yoshida, Yuzo
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 1999
Subjects:	Mechanisms of Resistance
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89127/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10223930/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.5.1163
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