The murine gene p27 (Kip1) is haplo-insufficient for tumour suppression

p27(Kip1) is a candidate human tumour-suppressor protein, because it is able to inhibit cyclin-dependent kinases and block cell proliferation(1-5). Abnormally low levels of the p27 protein are frequently found in human carcinomas, and these low levels correlate directly with both histological aggres...

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Bibliographic Details
Published in:Nature
Main Authors: Fero, Matthew L., Randel, Erin, Gurley, Kay E., Roberts, James M., Kemp, Christopher J.
Format: Artigo
Language:Inglês
Published: 1998
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5395202/
https://ncbi.nlm.nih.gov/pubmed/9823898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/24179
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