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A pathway in quiescent cells that controls p27(Kip1) stability, subcellular localization, and tumor suppression
We have created two knock-in mouse models to study the mechanisms that regulate p27 in normal cells and cause misregulation of p27 in tumors: p27(S10A), in which Ser10 is mutated to Ala; and p27(CK–), in which point mutations abrogate the ability of p27 to bind cyclins and CDKs. These two mutant all...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1356100/ https://ncbi.nlm.nih.gov/pubmed/16391232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1384406 |
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