SUMOylation regulates p27(Kip1) stability and localization in response to TGFβ

Exposure of normal and tumor-derived cells to TGFβ results in different outcomes, depending on the regulation of key targets. The CDK inhibitor p27(Kip1) is one of these TGFβ targets and is essential for the TGFβ-induced cell cycle arrest. TGFβ treatment inhibits p27(Kip1) degradation and induces it...

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Detalhes bibliográficos
Publicado no:J Mol Cell Biol
Main Authors: Lovisa, Sara, Citro, Simona, Sonego, Maura, Dall'Acqua, Alessandra, Ranzuglia, Valentina, Berton, Stefania, Colombatti, Alfonso, Belletti, Barbara, Chiocca, Susanna, Schiappacassi, Monica, Baldassarre, Gustavo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5943672/
https://ncbi.nlm.nih.gov/pubmed/26450989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjv056
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