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p27(kip1) Controls Cell Morphology and Motility by Regulating Microtubule-Dependent Lipid Raft Recycling
p27(kip1) (p27) is an inhibitor of cyclin/cyclin-dependent kinase complexes, whose nuclear loss indicates a poor prognosis in various solid tumors. When located in the cytoplasm, p27 binds Op18/stathmin (stathmin), a microtubule (MT)-destabilizing protein, and restrains its activity. This leads to M...
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| Asıl Yazarlar: | , , , , , , , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Microbiology (ASM)
2010
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2863592/ https://ncbi.nlm.nih.gov/pubmed/20194624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00723-09 |
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