p27(kip1) controls H-Ras/MAPK activation and cell cycle entry via modulation of MT stability

The cyclin-dependent kinase (CDK) inhibitor p27(kip1) is a critical regulator of the G1/S-phase transition of the cell cycle and also regulates microtubule (MT) stability. This latter function is exerted by modulating the activity of stathmin, an MT-destabilizing protein, and by direct binding to MT...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Fabris, Linda, Berton, Stefania, Pellizzari, Ilenia, Segatto, Ilenia, D’Andrea, Sara, Armenia, Joshua, Bomben, Riccardo, Schiappacassi, Monica, Gattei, Valter, Philips, Mark R., Vecchione, Andrea, Belletti, Barbara, Baldassarre, Gustavo
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653222/
https://ncbi.nlm.nih.gov/pubmed/26512117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508514112
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