p27(kip1) Controls Cell Morphology and Motility by Regulating Microtubule-Dependent Lipid Raft Recycling

p27(kip1) (p27) is an inhibitor of cyclin/cyclin-dependent kinase complexes, whose nuclear loss indicates a poor prognosis in various solid tumors. When located in the cytoplasm, p27 binds Op18/stathmin (stathmin), a microtubule (MT)-destabilizing protein, and restrains its activity. This leads to M...

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Hlavní autoři: Belletti, Barbara, Pellizzari, Ilenia, Berton, Stefania, Fabris, Linda, Wolf, Katarina, Lovat, Francesca, Schiappacassi, Monica, D'Andrea, Sara, Nicoloso, Milena S., Lovisa, Sara, Sonego, Maura, Defilippi, Paola, Vecchione, Andrea, Colombatti, Alfonso, Friedl, Peter, Baldassarre, Gustavo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863592/
https://ncbi.nlm.nih.gov/pubmed/20194624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00723-09
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