Identification of oncogenes collaborating with p27(Kip1) loss by insertional mutagenesis and high-throughput insertion site analysis
The p27(Kip1) protein is a cyclin-dependent kinase inhibitor that blocks cell division in response to antimitogenic cues. p27 expression is reduced in many human cancers, and p27 functions as a tumor suppressor that exhibits haploinsufficiency in mice. Despite the well characterized role of p27 as a...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123250/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12151601/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.162356099 |
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