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Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis
The cyclin-dependent kinase (CDK) inhibitors p21(Cip1) and p27(Kip1) are induced in response to anti-proliferative stimuli and block G(1)/S-phase progression through the inhibition of CDK2. Although the cyclin E–CDK2 pathway is often deregulated in tumors the relative contribution of p21(Cip1) and p...
Sparad:
| Huvudupphovsmän: | , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Oxford University Press
2002
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC126110/ https://ncbi.nlm.nih.gov/pubmed/12110586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf364 |
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