Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis
The cyclin-dependent kinase (CDK) inhibitors p21(Cip1) and p27(Kip1) are induced in response to anti-proliferative stimuli and block G(1)/S-phase progression through the inhibition of CDK2. Although the cyclin E–CDK2 pathway is often deregulated in tumors the relative contribution of p21(Cip1) and p...
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| Udgivet i: | EMBO J |
|---|---|
| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2002
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126110/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12110586/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf364 |
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