Identification of oncogenes collaborating with p27(Kip1) loss by insertional mutagenesis and high-throughput insertion site analysis

The p27(Kip1) protein is a cyclin-dependent kinase inhibitor that blocks cell division in response to antimitogenic cues. p27 expression is reduced in many human cancers, and p27 functions as a tumor suppressor that exhibits haploinsufficiency in mice. Despite the well characterized role of p27 as a...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Hwang, Harry C., Martins, Carla P., Bronkhorst, Yvon, Randel, Erin, Berns, Anton, Fero, Matthew, Clurman, Bruce E.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2002
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123250/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12151601/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.162356099
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