Temozolomide Treatment for Aggressive Pituitary Tumors: Correlation of Clinical Outcome with O(6)-Methylguanine Methyltransferase (MGMT) Promoter Methylation and Expression

Context: The typically indolent behavior of pituitary tumors is juxtaposed with high rates of tumor cell invasion into adjacent dural structures, and occasional aggressive behavior. Although clinically significant invasion and malignant transformation remain uncommon, there are limited treatment opt...

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Pubblicato in:J Clin Endocrinol Metab
Autori principali: Bush, Zachary M., Longtine, Janina A., Cunningham, Tracy, Schiff, David, Jane, John A., Vance, Mary Lee, Thorner, Michael O., Laws, Edward R., Lopes, M. Beatriz S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2010
Soggetti:
JCEM Online: Hot Topics in Translational Endocrinology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393383/
https://ncbi.nlm.nih.gov/pubmed/20668043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2010-0441
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