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The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction
Telomeres are protected by shelterin, a six-subunit protein complex that represses the DNA damage response (DDR) at chromosome ends. Extensive data suggest that TRF2 in shelterin remodels telomeres into the t-loop structure, thereby hiding telomere ends from double-stranded break repair and ATM sign...
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| Vydáno v: | Genes Dev |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Cold Spring Harbor Laboratory Press
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5393053/ https://ncbi.nlm.nih.gov/pubmed/28381412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.294108.116 |
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