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Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization

The regulation of telomere length in mammals is crucial for chromosome end-capping and thus for maintaining genome stability and cellular lifespan. This process requires coordination between telomeric protein complexes and the ribonucleoprotein telomerase, which extends the telomeric DNA. Telomeric...

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Bibliografiske detaljer
Udgivet i:Nat Rev Mol Cell Biol
Main Authors: Lim, Ci Ji, Cech, Thomas R.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221230/
https://ncbi.nlm.nih.gov/pubmed/33564154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41580-021-00328-y
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