The structure of human CST reveals a decameric assembly bound to telomeric DNA

The CTC1-STN1-TEN1 (CST) complex is essential for telomere maintenance and resolution of stalled replication forks genome-wide. Here, we report the 3.0-angstrom cryo–electron microscopy structure of human CST bound to telomeric single-stranded DNA (ssDNA), which assembles as a decameric supercomplex...

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Bibliografske podrobnosti
izdano v:Science
Main Authors: Lim, Ci Ji, Barbour, Alexandra T., Zaug, Arthur J., Goodrich, Karen J., McKay, Allison E., Wuttke, Deborah S., Cech, Thomas R.
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7559292/
https://ncbi.nlm.nih.gov/pubmed/32499435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaz9649
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