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The role of caloric load and mitochondrial homeostasis in the regulation of the NLRP3 inflammasome

Sterile inflammation is a cornerstone of immune activation in obesity and type 2 Diabetes Mellitus. The molecular underpinnings of this inflammation include nutrient excess-mediated activation of the innate immune NLRP3 inflammasome. At the same time, disruption of mitochondrial integrity is emergin...

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Bibliografische gegevens
Gepubliceerd in:Cell Mol Life Sci
Hoofdauteurs: Traba, Javier, Sack, Michael N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer International Publishing 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391300/
https://ncbi.nlm.nih.gov/pubmed/27942750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-016-2431-7
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