The NLRP3 inflammasome plays key role in the regulation of intestinal homeostasis

Attenuated innate immune responses to the intestinal microbiota have been linked to the pathogenesis of Crohn’s disease (CD). Recent genetic studies have revealed that hypofunctional mutations of NLRP3, a member of the NOD-like receptor (NLR) superfamily, are associated with an increased risk of dev...

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Библиографические подробности
Главные авторы: Hirota, Simon A., Ng, Jeffrey, Lueng, Alan, Khajah, Maitham, Parhar, Ken, Li, Yan, Lam, Victor, Potentier, Mireille S., Ng, Kelvin, Bawa, Misha, McCafferty, Donna-Marie, Rioux, Kevin P., Ghosh, Subrata, Xavier, Ramnik J., Colgan, Sean P., Tschopp, Jurg, Muruve, Daniel, MacDonald, Justin A., Beck, Paul L.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3026862/
https://ncbi.nlm.nih.gov/pubmed/20872834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ibd.21478
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