Exaggerated IL-15 and Altered Expression of foxp3+ Cell-Derived Cytokines Contribute to Enhanced Colitis in Nlrp3−/− Mice

The pathogenesis of Crohn's disease (CD) involves defects in the innate immune system, impairing responses to microbes. Studies have revealed that mutations NLRP3 are associated with CD. We reported previously that Nlrp3−/− mice were more susceptible to colitis and exhibited reduced colonic IL-...

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Vydáno v:Mediators Inflamm
Hlavní autoři: Hirota, Simon A., Ueno, Aito, Tulk, Sarah E., Becker, Helen M., Schenck, L. Patrick, Potentier, Mireille S., Li, Yan, Ghosh, Subrata, Muruve, Daniel A., MacDonald, Justin A., Beck, Paul L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5005544/
https://ncbi.nlm.nih.gov/pubmed/27610005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/5637685
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